Fatal multiorgan failure in baclofen overdose: An autopsy case report

---

Case Report

Author Details : Alagarasan Naveen, Manas R Sahu*, Manoj K Mohanty, Rajanikanta Swain, Anupam Dey

Volume : 9, Issue : 3, Year : 2022

Article Page : 124-127

https://doi.org/10.18231/j.ijfcm.2022.027

Suggest article by email

---

Abstract

Baclofen is a synthetic derivative of GABA and is used as a muscle relaxant or antispasmodic agent. It is used in the management of various muscle spasticity resulting from conditions such as cerebral palsy, spinal cord injuries, and stroke. The reported potential adverse effects following overdose are marked impairment in consciousness, acute kidney injury, seizures, coma, and respiratory failure. Since there is no specific antidote available to treat baclofen toxicity, the mainstay of management remains supportive treatment. Herein we describe a case of baclofen overdose in a 62-years-old male who consumed 15 tablets of 25 mg tablets of baclofen (375 mg) and died due to multiorgan failure after 5 days of poisoning. Although many reports in the published medical literature describe the clinical manifestations and the management of baclofen toxicity, only a few reports presented the fatality in baclofen overdose. Furthermore, no report documented the death following lethal multiorgan failure resulting from baclofen overdose, and from India to the best of our knowledge.
 

Keywords: Baclofen, Multiorgan failure, Toxicology, Poison, Hemodialysis, Autopsy, Overdose.

How to cite : Naveen A, Sahu M R, Mohanty M K, Swain R, Dey A, Fatal multiorgan failure in baclofen overdose: An autopsy case report. Indian J Forensic Community Med 2022;9(3):124-127

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.