Design, synthesis and evaluation of chalcones as anti-microbial agent

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Original Article

Author Details : Senthilraja Manivannan*

Volume : 7, Issue : 3, Year : 2020

Article Page : 120-123

https://doi.org/10.18231/j.ijfcm.2020.026

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Abstract

2, 4-dichloro-5’fluoro-1-ene-2-(4-hydroxyphenyl) phenone (EHP) was synthesized using 4- hydroxybenzaldehyde and 2,4-dichloro-5-fluoro acetophenone (DFA). 4-[3-(2, 4-dichloro-5-fluorophenyl)-3-oxoprop-1-en-1-yl]phenyl acrylate (EAP) was prepared by reacting EHP with acryloyl  hloride using ethyl methyl ketone (EMK) as a solvent in the presence of triethylamine (TEA) as a base at 0-50. Poly (EAP) was prepared by solution polymerization technique using benzoyl peroxide (BPO) as a free radical initiator and EMK as a solvent at 70 ± 10. EHP, EAP and poly (EAP) were characterized by Infrared, proton NMR and 13C NMR techniques. Anti-microbial activity of the DFA, EHP, EAP and poly (EAP) were tested on three different ATCC microorganisms (E.coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853 and Salmonella Typhi ATCC 6539). The minimum concentration of the drug needed to inhibit the growth of the bacteria was estimated using photometry assay method.

Keywords: Chalcones, Antimicrobials, Polymerization, Dimethyl sulphoxide.

How to cite : Manivannan S , Design, synthesis and evaluation of chalcones as anti-microbial agent. Indian J Forensic Community Med 2020;7(3):120-123

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